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Organic compounds that contain a carboxyl group bonded to an organic functional group; carboxyl groups consist of a carbonyl group bonded to a hydroxy group. Includes compounds that are derived from carboxylic acids.
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Ixazomib Citrate (MLN9708) is a prodrug of Ixazomib (MLN2238) which is a selective orally bioavailable inhibitor of 20S proteasome that inhibits the chymotrypsin-like proteolytic ( 5) site with IC50 of 3 4 nM and Ki of 0 93 nM respectively Ixazomib (MLN2238) also inhibits caspase-like ( 1) and trypsin-like ( 2) proteolytic sites with IC50 of 31 nM and 3500 nM respectively
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Zoledronic acid (Zoledronate CGP-4244) monohydrate a nitrogen-containing bisphosphonate is a potent osteoclast inhibitor which induces apoptosis in osteoclasts by inhibiting enzymes of the mevalonate pathway and preventing the isoprenylation of small GTP-binding proteins such as Ras and Rho
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Fmoc-NH-PEG1-CH2COOH is an Fmoc-protected PEG1 linker used as a cleavable linker for antibody-drug conjugate (ADC) synthesis and as a PEG-based PROTAC linker. The compound is supplied as a white powder with reported high purity and is available in multiple pack sizes, including a 5 G pack.
Fmoc-protected amine with a PEG1 spacer and terminal carboxylic acid.
Used as a cleavable linker in ADC and PROTAC syntheses.
Supplied as a white powder; multiple pack sizes available.
Reported high purity suitable for research applications.
Chemical identifiers: CAS 260367-12-2; molecular weight 341.36; formula C19H19NO5.
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Bromo-PEG1-CH2COOH is a PROTAC linker, designed for use in the synthesis of PROTACs. These molecules exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins, by connecting an E3 ubiquitin ligase ligand to a target protein ligand.
Used as a PROTAC linker
Designed for PROTAC synthesis
Contains two ligands connected by a linker
One ligand targets an E3 ubiquitin ligase
Other ligand targets a protein
Exploits the ubiquitin-proteasome system
Enables selective degradation of target proteins
For research use only
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SPD-473 citrate is the citrate salt of a triple reuptake inhibitor that blocks serotonin, dopamine, and norepinephrine transporters. Supplied for research use, it is a characterized white to off-white solid with documented purity and solubility data for in vitro and in vivo studies.
Acts as a serotonin, dopamine, and norepinephrine reuptake inhibitor.
High purity (99.8%).
Molecular weight 552.47 g/mol.
White to off-white solid suitable for laboratory handling.
High solubility in DMSO (100 mg/mL); in vivo formulation protocols provided.
Available in 1 mg, 5 mg, 10 mg, and 25 mg pack sizes for screening and pilot studies.
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